1. Histological criteria for effectiveness of chemo- and radio-therapy for gastrointestinal tumors
  2. Study of premalignant and in-situ carcinoma for Bile-duct and pancreas group
  3. Histopathological study towardsselection of treatment modalitiesand outcome prediction in head and neck cancer
  4. Studies by Breast Group
  5. Hepatocarcinogenesis using experimental liver cancer models
  6. Pathological studies for gynecological malignancies
  7. Diagnostic and etiologic studies for lung cancers
  8. Clinicopathological studies with aids of chromosome analysis for genitourinary cancers
  9. Pathological and molecular studies for bone and soft tissue tumors
  10. Pathological and molecular studies for hematological neoplasms

Pathological studies for gynecological malignancies

The gynecological tumor group works chiefly with uterus and ovaries. We examine biopsy and surgery materials closely and provide clinicians with pathological information for appropriate treatment. Regarding tumors of uterine cervix, the most important information is whether tumors are invasive or not, and to know that, conization is performed and materials are subject to our examination. On the other hand, tumor depth and presence/absence of lymphatic invasion at surgery are most important for tumors of uterine corpus to choose appropriate adjuvant therapies. For ovarian tumors, detailed histological typing is important for choice of therapy as well as diagnosing as benign or malignant, and therefore histological diagnosis by intra-operative frozen section is indispensable and routine practice here in our deparment.

As research activities, we analyze cervical cancers and other relevant disorders that are related strongly to human papilloma virus (HPV) to follow and treat such patients. Specifically, we focus on histology of high-risk HPV infection and true tumorous conditions.

Publication list:

  • Furuta R, Hirai Y, Katase K, Akiyama F, Kitagawa T et al. Ectopic chromosome around centrosome in metaphase cells as a marker of high-risk human papillomavirus-associated cervical intraepithelial neoplasias. Int J Cancer 106:167-71, 2003.

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