- Histological criteria for effectiveness of chemo- and radio-therapy for gastrointestinal tumors
- Study of premalignant and in-situ carcinoma for Bile-duct and pancreas group
- Histopathological study towards selection of treatment modalities and outcome prediction in head and neck cancer
- Studies by Breast Group
- Hepatocarcinogenesis using experimental liver cancer models
- Pathological studies for gynecological malignancies
- Diagnostic and etiologic studies for lung cancers
- Clinicopathological studies with aids of chromosome analysis for genitourinary cancers
- Pathological and molecular studies for bone and soft tissue tumors
- Pathological and molecular studies for hematological neoplasms
Study of premalignant and in-situ carcinoma for Bile-duct and pancreas group
The bile-duct system and pancreas group
Members: Drs. Y. Kato, N. Yamamoto, M. Katori, T.Noro
The bile-duct system and pancreas group carries out pathological diagnosis of operation materials of tumors involved in bile ducts and pancreas. As research activities, we are elucidating the following themes.
- Study of premalignant and in-situ carcinomas.
We analyze in-situ carcinomas (PanIN 3) histologically and molecular-biologically as compared with invasive ones and contribute to early detection of refractory carcinomas.
- Invasive carcinomas derived from intraductal papillary mucinous neoplasims (IPMN).
It is known that invasive carcinomas derived from IPMN have better prognosis than usual invasive carcinomas. Under multi-institutional collaboration, we are examining histological criteria of invasion including minimal invasion.
- State of stroma and grade of malignancy.
We investigate relationships between degree of development of stroma such as blood vessels and fibrous tissues and grade of malignancy.